Stephen Z. Lu

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Hey there, welcome to my blog! My name is Stephen and I am a first year PhD student at UC Berkeley supervised by Prof. Yun S. Song.

I am broadly interested in developing data-driven methods to model biomolecular systems — with a focus on protein dynamics and evolution.

More concretely, my current research directions include:

  • Devising novel methods for molecular design and optimization ([1])
  • Evolution-informed representation learning for proteins and DNA
  • Generative modeling of protein dynamics ([2], [3])

I have previously been:

In my free time, I love playing pickup basketball, composing mostly funky (and a few serious) songs on the piano, discovering new hiking trails (my profile pic above was taken atop Mt. Wakakusa in Nara, Japan), and spending time with my family and friends.

Feel free to reach out stephen.lu@berkeley.edu if you’d like to chat about research or meet for coffee in the Bay Area!

selected publications

2025

  1. scigym.png
    Measuring Scientific Capabilities of Language Models with a Systems Biology Dry Lab
    Haonan Duan*, Stephen Zhewen Lu*, Caitlin Fiona Harrigan, and 5 more authors
    arXiv preprint arXiv:2507.02083, 2025
  2. eba.png
    Aligning Protein Conformation Ensemble Generation with Physical Feedback
    Jiarui Lu, Xiaoyin Chen, Stephen Zhewen Lu, and 4 more authors
    In ICML, 2025
  3. slm.png
    Structure Language Models for Protein Conformation Generation
    Jiarui Lu, Xiaoyin Chen, Stephen Zhewen Lu, and 4 more authors
    In ICLR, 2025

2024

  1. omics-gfn.jpg
    Cell morphology-guided small molecule generation with gflownets
    Stephen Zhewen Lu, Ziqing Lu, Ehsan Hajiramezanali, and 4 more authors
    In ICML Workshop SPIGM, 2024